Journal article
A zebrafish model of inflammatory lymphangiogenesis
KS Okuda, JP Misa, SH Oehlers, CJ Hall, F Ellett, S Alasmari, GJ Lieschke, KE Crosier, PS Crosier, JW Astin
Biology Open | COMPANY BIOLOGISTS LTD | Published : 2015
DOI: 10.1242/bio.013540
Abstract
Inflammatory bowel disease (IBD) is a disabling chronic inflammatory disease of the gastrointestinal tract. IBD patients have increased intestinal lymphatic vessel density and recent studies have shown that this may contribute to the resolution of IBD. However, the molecular mechanisms involved in IBD-associated lymphangiogenesis are still unclear. In this study, we established a novel inflammatory lymphangiogenesis model in zebrafish larvae involving colitogenic challenge stimulated by exposure to 2,4,6-trinitrobenzenesulfonic acid (TNBS) or dextran sodium sulphate (DSS). Treatment with either TNBS or DSS resulted in vascular endothelial growth factor receptor (Vegfr)-dependent lymphangioge..
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Awarded by State Government of Victoria
Funding Acknowledgements
J.W.A., J.P.M., S.H.O., C.J.H., K.E.C. and P.S.C. were supported by the Ministry of Business, Innovation and Employment grant [UOAX0813] awarded to K.E.C. and P.S.C. J.W.A., J.P.M., K.E.C. and P.S.C. were supported by a Health Research Council of New Zealand project grant [14/105] awarded to P.S.C and J.W.A. K.S.O. was supported by the Ministry of Science, Technology and Innovation scholarship (Malaysia). S.H.O. was supported by the Australian National Health and Medical Research Council CJ Martin Early Career Fellowship. F.E. was supported by an Australian Postgraduate Award and Walter and Eliza Hall Institute of Medical Research Edith Moffatt Scholarship. G.J.L. was supported by the National Health and Medical Research Council [Grant numbers 637394, 1044754 and 1069284]. The Australian Regenerative Medicine Institute is supported by funds from the State Government of Victoria and the Australian Federal Government.